Death Race 2 takes place in the very near future, as the United States economy begins to decline and violent crime starts to spiral out of control. To contain the growing criminal population, a vast network of for-profit, private prisons springs up, creating a lawless subculture ruled by gangs, cold-blooded killers and sociopaths. The worst of these prisons is Terminal Island. Convicted cop-killer Carl Lucas arrives on the Island to serve his life sentence just as ruthlessly ambitious television personality September Jones launches the ultimate reality show, Death Race. A brutal prison yard demolition derby that pits prisoners against each other in steel reinforced, heavily armed vehicles, Death Race offers the winner the ultimate prize: freedom — if he can survive to enjoy it. When Lucas signs up to be a driver, the stage is set for the birth of a legendary racer.
When lovelorn Michael arrives in Berlin to return a set of keys to his ex-girlfriend, Gabi, as an excuse to see her again, he finds her apartment empty save for a couple of plumbers making repairs to the central heating. Just as Michael learns from the plumber’s apprentice, Harper, that Gabi has popped out for a while but will return soon, the apprentice is attacked by his boss who has unexpectedly and inexplicably transformed into a raging madman. Together, Michael and Harper manage to bundle the crazed plumber out of the apartment and barricade themselves safely inside. Within minutes, they find themselves trapped in apartment block under siege from a horde of similarly insane people, apparently hungry for human flesh.
The radio news reports of a deadly virus spreading throughout Berlin, transmitted by body fluids via bites and bleeding wounds. The result is a city overrun by bloodthirsty zombies. Surrounded by the undead, Michael and Harper have to figure out how to stay alive long enough to get out of the building safely and, if Michael has anything to do with it, find Gabi along the way.