After being caught on camera brutally beating a clown rapist, police officer Mary Collins is informed by her commanding officer that she needs counseling.
Her therapist quickly concludes that she suffers from extreme PMS and enrolls her in a drug trial for the new menstrual wonder drug Corybantic.
Mary responds positively until a devastating incident throws her into a monstrous drug-induced killing frenzy. Soon everyone who comes into contact with the PMS cop realizes it IS her time of the month.